Endocrine Abstracts

Brown adipose tissue (BAT) is an insulin sensitive organ having a very high uptake of glucose per gram of tissue. The role of insulin on glucose uptake in BAT is still poorly understood, moreover, it is not clear whether BAT insulin function is compromised with obesity. We used a small animal PET/CT imaging approach to analyse insulin function in vivo in lean and obese mice using a glucose analogue PET tracer (18F-FDG). Three groups of mice were analysed afte...

Obesity is characterized by an increase of endocannabinoid circulating levels as anandamide (AEA) and 2-arachidonoyl-glycerol (2AG). Whether these lipids represent a biomarker of dysmetabolism or merely reflect the fat mass spill-over is still unclear. After generating rigorous, gender specific, plasma reference intervals by 2D-liquid chromatography-tandem mass spectrometry, we defined the 97.5thcentile of endocannabinoid distribution in the normal population as the cut-off ab...